Ep. 73: What to Know About Advanced Systemic Mastocytosis
Part of the series: Allergy, Asthma & Immunology Innovations Podcast
This podcast was made in partnership with Allergy & Asthma Network. We thank Blueprint Medicines for sponsoring this podcast.
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Have you ever searched for information on mast cell disease only to be overwhelmed by alarming topics like cancer and stem cell transplants?
Our guest, Dr. Marina Kremyanskaya, joins hosts Dr. G and Kortney to provide insight into the progression of systemic mastocytosis and the available treatment options to improve quality of life and extend lifespan.
Dr. Kremyanskaya distinguishes between indolent and aggressive systemic mastocytosis, shedding light on warning signs indicating disease progression. She offers a detailed exploration of treatment approaches for aggressive mastocytosis, highlighting the evolving treatment plan and differing prognosis from indolent cases. Additionally, Dr. Kremyanskayaa delves into the concept of myeloid malignancy, providing insight into the more challenging aspects of advanced systemic mastocytosis progression.
We also dive into stem cell transplants as a potential cure for advanced systemic mastocytosis. Dr. Kremyanskaya explains why this option is not immediately pursued due to the complexity of the procedure and the risk of graft-versus-host disease (GvHD), a potential complication associated with stem cell transplants.
What we cover in our about advanced systemic mastocytosis:
Understanding indolent systemic mastocytosis
Signs indicating progression to advanced mastocytosis.
Treatment strategies for aggressive mastocytosis and associated prognosis.
Explanation of advanced systemic mastocytosis with or without hematologic malignancy.
Definition of myeloid malignancy.
Understanding the impact of advanced systemic mastocytosis on organs.
The effectiveness of early treatment in slowing down the progression.
The role of stem cell transplant in treating mastocytosis.
Stem cell transplant and associated risks
Role of chemotherapy in stem cell transplant.
Overview of graft-versus-host disease.
Addressing whether stem cell transplant serves as a cure for mast cell disease.
More in the Mast Cell Disease Series:
Resources about mast cell disease:
Mast Cell Disease Overview: https://allergyasthmanetwork.org/health-a-z/mast-cell-diseases/
What is Anaphylaxis? https://allergyasthmanetwork.org/anaphylaxis/
What is Epinephrine? https://allergyasthmanetwork.org/anaphylaxis/what-is-epinephrine/
The Mast Cell Disease Society: https://tmsforacure.org/
About Dr. Kremyanskaya
Marina Kremyanskaya, MD, PhD, is an Associate Professor at Mount Sinai's Icahn School of Medicine, specializing in hematology and oncology. As the medical director of the inpatient oncology unit at The Mount Sinai Hospital, she oversees the care of hospitalized cancer patients. Dr. Kremyanskaya focuses on myeloid malignancies and actively contributes to developing novel therapies and leading clinical trials.
More about Dr. Kremyanskaya: https://profiles.mountsinai.org/marina-kremyanskaya
Bone Marrow Stem Cells
During the podcast, Dr. Kremyanskaya discusses stem cells and the many cells related to mastocytosis. This image helps to illustrate the path explained in the episode.
More about bone marrow anatomy. https://www.thoughtco.com/bone-marrow-anatomy-373236
We thank Blueprint Medicines for sponsoring this podcast.
Time Stamps
Ep. 73 What is Advanced Systemic Mastocytosis?
00:01:07 Introduction to Dr. Kremyanska
00:01:42 Understanding indolent systemic mastocytosis
00:04:45 Signs of advancing mastocytosis
00:08:28 Treatment changes and prognosis in aggressive mastocytosis
00:12:32 Explanation of advanced systemic mastocytosis with or without hematological malignancy
00:14:21 Insight into myeloid malignancies
00:16:38 Bone marrow's role as an organ
00:16:49 Organs most affected by advanced systemic mastocytosis
00:17:39 Importance of early treatment in slowing advanced systemic mastocytosis
00:19:22 Consideration of stem cell transplant for mastocytosis
00:21:32 Role of chemotherapy in stem cell transplant
00:23:16 Understanding graft-versus-host disease
00:24:42 Exploring the potential of stem cell transplant as a cure for mast cell disease
